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In most cases, the entry gate of infection is the respiratory tract. Once in the bronchi and alveoli, histoplasmic spores turn into a tissue form and cause the development of the primary focus in the lungs and regional lymph nodes. In the lung tissue, a granulomatous process develops with an outcome in necrosis, ulceration or calcification, less often - abscess formation. Acute pulmonary histoplasmosis is similar in its pathogenesis to primary pulmonary tuberculosis. Once in the systemic circulation, histoplasma causes sensitization of ranitidine and the production of specific antibodies. Sometimes the pathological process is limited to this, which corresponds to the subclinical form of histoplasmosis. In other cases, the hematogenous spread of a fungal infection causes the development of disseminated histoplasmosis.